A bioinformatic survey of RNA isoform diversity and expression across 9 GTEx tissues using long-read sequencing data
This study represents a broad bioinformatic survey of the RNA isoform landscape, demonstrating isoform diversity across nine tissues and emphasizes the need for further verification, validation, and functional annotation research to better understand how individual isoforms from a single gene body contribute to human health and disease.
Authors
- Mark E. Wadsworth (ORCID: https://orcid.org/0000-0001-6358-1111)
- Kayla A. Nations
- J. Anthony Brandon (ORCID: https://orcid.org/0009-0009-4094-7278)
- Madeline L. Page (ORCID: https://orcid.org/0000-0001-9990-1500)
- Mark Ebbert (ORCID: https://orcid.org/0000-0001-9158-4440)
- Bernardo Aguzzoli Heberle (ORCID: https://orcid.org/0000-0002-6177-9316)
- David W. Fardo (ORCID: https://orcid.org/0000-0002-7207-4696)
- Lacey A. Gordon
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s12864-025-11919-w
- Citations
- 1
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- University of Kentucky
- National Institutes of Health