Evaluation of [18F]MNI-1054, a novel PET ligand for lysine-specific histone demethylase 1A (LSD1), in non-human primates
[<sup>18</sup>F]MNI-1054 displayed acceptable brain penetrance, kinetics and LSD1 specificity as well as an acceptable dosimetry. Overall, these findings show its suitability as a viable PET probe to assess the binding profile of LSD1 inhibitors in the brain and support further evaluation in humans.
Authors
- Paul McQuade (ORCID: https://orcid.org/0000-0003-0282-0208)
- Olivier Barret (ORCID: https://orcid.org/0000-0003-4247-184X)
- Ozlem Yardibi
- Christine Sandiego (ORCID: https://orcid.org/0000-0001-7490-2494)
- Cristian Constantinescu (ORCID: https://orcid.org/0000-0001-5709-9476)
- Akihiro Takano
- Yoann Petibon (ORCID: https://orcid.org/0000-0003-3067-4607)
- J. Tauscher
- Adam J. Schwarz (ORCID: https://orcid.org/0000-0003-0651-8487)
Institutions
- Invicro (United States) (US)
- Takeda (United States) (US)
- Takeda (Japan) (JP)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s13550-025-01350-3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00