Testing if vitamin K1 reduces the progression of non-severe calcific aortic stenosis: design and rationale of the Prevention of Aortic Stenosis Progression Phylloquinone Ossification Reduction Trial (PASSPORT)
PASSPORT will be prospective, randomized, double-blind clinical trial powered to demonstrate if oral supplementation with vitamin K1 reduces the progression of valvular calcification and echocardiographic severity of disease in patients with non-severe CAS. The trial results will have implications for the management of CAS, for which there is currently no medical treatment.
Authors
- William Courtney (ORCID: https://orcid.org/0000-0002-8969-658X)
- A. Dorai-Raj
- J. Bellinge (ORCID: https://orcid.org/0000-0001-8257-7361)
- Jonathan M. Hodgson (ORCID: https://orcid.org/0000-0001-6184-7764)
- Jarryd Walker
- Carl Schultz (ORCID: https://orcid.org/0000-0002-0847-4361)
- Adil Rajwani (ORCID: https://orcid.org/0000-0002-4196-7205)
- Graham S. Hillis (ORCID: https://orcid.org/0000-0003-2417-4673)
- Tom Gilbert (ORCID: https://orcid.org/0000-0002-2570-3963)
Institutions
- Edith Cowan University (AU)
- The University of Western Australia (AU)
- Curtin University (AU)
- Royal Perth Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/ehjopen/oeaf144
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00