Neuroprotective effects of SRS11-92 against oxidative stress–induced senescence via Nrf2/HO-1/NF-κB in Alzheimer’s disease models
SRS11-92 exerts significant neuroprotective effects, attributable to reducing stress-induced senescence via activating Nrf2/HO-1 and constraining NF-κB signalling.
Authors
- Yu Song (ORCID: https://orcid.org/0000-0002-4185-2256)
- Furong Wang (ORCID: https://orcid.org/0000-0001-8693-7301)
- Zhongya Gu
- Huấn Cao (ORCID: https://orcid.org/0000-0001-9540-4734)
- Qingqing Jiang (ORCID: https://orcid.org/0009-0004-6229-3627)
- Chengchao Zuo (ORCID: https://orcid.org/0000-0002-1419-7989)
- Xiang Chen (ORCID: https://orcid.org/0009-0005-5253-5175)
- Yuming Guo (ORCID: https://orcid.org/0000-0002-1766-6592)
- Yaqi Huang (ORCID: https://orcid.org/0000-0001-6811-5021)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Inflammopharmacology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1007/s10787-025-02072-7
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology