Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study

There was no significant association between topical antifungal use during the first trimester of pregnancy and the risk of MCMs in infants in Japan.

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Publication Details

Journal
Pharmacoepidemiology and Drug Safety
Published
2025-12-01
DOI
https://doi.org/10.1002/pds.70274
Primary Topic
Pregnancy and Medication Impact
Type
article
Field-Weighted Citation Impact
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article

Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study

Taku Obara, Nobuyuki Takahashi, Ryo Obara, Azusa Hara et al.
Pharmacoepidemiology and Drug Safety
Pregnancy and Medication Impact
article

Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study

Taku Obara, Nobuyuki Takahashi, Ryo Obara, Azusa Hara, Tomofumi Ishikawa, Kiyoshi Hayasaka, Emiko Sato, Nariyasu Mano, Takamasa Sakai, H. Watanabe, Noriyuki Iwama, Aki Shimizu, Aoi Noda, Mami Ishikuro, Masatsugu Orui, Motohiko Adomi, Shinichi Kuriyama, Genki Shinoda, Yuki Yoshida, Kei Morishita, Seiko Yamakoshi, Tadaharu Kunitoki
article en

Abstract

There was no significant association between topical antifungal use during the first trimester of pregnancy and the risk of MCMs in infants in Japan.

Pharmacoepidemiology and Drug SafetyVol. 34(12)
Harvard University (US), Tohoku University (JP), Tohoku University Hospital (JP), Tohoku Medical Megabank Organization (JP), Tohoku Medical and Pharmaceutical University (JP), Showa Pharmaceutical University (JP), Meijo University (JP)
Openalex Percentile: Top 51%
Pregnancy and Medication Impact
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Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study — Taku Obara, Nobuyuki Takahashi, et al. · Pharmacoepidemiology and Drug Safety (2025) | TGRS Research Map | TGRS