The impact of asparaginase phenotype-related single nucleotide polymorphisms on prognosis in pediatric B-cell precursor acute lymphoblastic leukemia
These findings underscore the importance of asparaginase phenotype-related SNP, ADSL (793-49A > C), in personalized treatment strategies based on genetic profiling and clinical parameters, potentially enhancing therapeutic efficacy and patient outcomes in pediatric BCP-ALL.
Authors
- Jiayue Qin (ORCID: https://orcid.org/0000-0003-4721-0016)
- Diying Shen (ORCID: https://orcid.org/0000-0002-2870-1154)
- Xiaojun Xu (ORCID: https://orcid.org/0000-0002-0127-2812)
- Jingying Zhang (ORCID: https://orcid.org/0000-0001-8929-6669)
- Xu Cai (ORCID: https://orcid.org/0000-0001-5675-5638)
- Tian Xia (ORCID: https://orcid.org/0009-0006-6815-4008)
- Lixia Liu (ORCID: https://orcid.org/0009-0000-7766-0195)
Institutions
- Beijing VDJBio (China) (CN)
- Children's Hospital of Zhejiang University (CN)
- National Clinical Research (US)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Xiangyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s40001-025-03467-6
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province