Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis
cTph cells are expanded and exhibit an activated, pro-inflammatory profile with a cTph2-skewed distribution in active GPA-patients. Their association with disease activity may support a potential role in disease pathogenesis and highlight their potential as therapeutic targets, warranting further investigation.
Authors
- Wayel H. Abdulahad (ORCID: https://orcid.org/0000-0003-3109-4487)
- Oliver Wood
- Matthew A. Jackson-Wood
- Samuel J. Bullers (ORCID: https://orcid.org/0000-0001-5643-5845)
- Malte Borggrewe (ORCID: https://orcid.org/0000-0001-9644-288X)
- Peter Heeringa (ORCID: https://orcid.org/0000-0001-8684-763X)
- Abraham Rutgers (ORCID: https://orcid.org/0000-0002-1641-6890)
- Hang Liao (ORCID: https://orcid.org/0000-0002-3475-2177)
- Nanthicha Inrueangsri (ORCID: https://orcid.org/0009-0008-1028-8403)
Institutions
- University Medical Center Groningen (NL)
- Gilead Sciences (United Kingdom) (GB)
- Oldham Council (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1186/s13075-025-03701-w
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00