Decorin Deficiency Promotes D‐Galactose–Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway
The comprehensive results show that decorin plays a sarcoprotective role by activating the ITGB1/Akt/mTOR pathway and may serve as a potential therapeutic reagent in age-associated sarcopenia.
Authors
- Mengxue Zhang (ORCID: https://orcid.org/0000-0002-8587-4334)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-2211-8539)
- Li-Li Chen (ORCID: https://orcid.org/0000-0002-9593-8004)
- Jin Wang (ORCID: https://orcid.org/0000-0002-7278-9368)
- Xiaoqin Luo (ORCID: https://orcid.org/0009-0002-2838-7393)
- Zhe Yang (ORCID: https://orcid.org/0000-0003-4082-6088)
- Xiuli Bi (ORCID: https://orcid.org/0000-0002-9065-1151)
- Jiabing Lian
- Ruichang Wang
- Renato V. lozzo
Institutions
- Liaoning University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Sidney Kimmel Cancer Center (US)
- Shenyang University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70144
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61