Molecular imaging of fibroblast activation in systemic sclerosis using [18F]AlF-NOTA-FAPI-04 PET/CT: a prospective cohort study
[¹⁸F]AlF-NOTA-FAPI-04 PET/CT provides a noninvasive, integrative imaging platform for mapping fibroblast activation across multiple organs in SSc. It demonstrated potential for detection of fibrotic burden and inter-organ metabolic profiling. Its sensitivity in gastrointestinal and cutaneous involvement remains limited, warranting further optimization.
Authors
- Rong Mu (ORCID: https://orcid.org/0000-0002-9111-2643)
- Yi Wu (ORCID: https://orcid.org/0000-0002-2322-6825)
- Xiangyang Li (ORCID: https://orcid.org/0009-0001-3360-7381)
- Annan Zhang (ORCID: https://orcid.org/0000-0001-6664-9417)
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Weifang Zhang (ORCID: https://orcid.org/0000-0003-3879-1285)
- Hui Wei (ORCID: https://orcid.org/0000-0003-1674-3792)
- Hui Li (ORCID: https://orcid.org/0000-0002-4611-7808)
- Song Xue (ORCID: https://orcid.org/0000-0003-1934-6215)
- Meixin Zhao
- Zeyang Wang (ORCID: https://orcid.org/0000-0002-3030-7164)
- Meng Wang (ORCID: https://orcid.org/0000-0001-7648-9955)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Vienna General Hospital (AT)
- Beijing Chest Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1007/s00259-025-07586-4
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Third Hospital