Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-β Activating Kinase 1-C-Jun N-terminal Kinase/p38 Signaling Pathway
This study revealed that Rhbdf2 exacerbates HIRI by activating the TAK1- JNK/p38 axis, whereas Cop1-mediated Rhbdf2 ubiquitination and degradation can significantly inhibit this process. These findings provide potential therapeutic targets and insights for the clinical treatment of HIRI.
Authors
- Wenzhi Guo (ORCID: https://orcid.org/0000-0002-0821-1318)
- Tongtong Wu (ORCID: https://orcid.org/0000-0002-0913-9194)
- Mingjie Ding (ORCID: https://orcid.org/0000-0001-8100-8183)
- Hao Li (ORCID: https://orcid.org/0000-0002-9377-1706)
- Wendong Li (ORCID: https://orcid.org/0000-0001-8344-419X)
- Zhicheng Guan (ORCID: https://orcid.org/0009-0003-5999-4767)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101695
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00