Unlocking the Potential of Polar Organometallic Reagents in Sustainable Solvents

Abstract Polar organometallic reagents of the s- and d-block elements are key tools for C–C and C–heteroatom bond formation. Recent advances show that these highly reactive species can operate efficiently in sustainable solvents like water and deep eutectic solvents, under air and at room temperature. Acting as living solvents, these media enable sustainable organometallic transformations and redefine classical reactivity paradigms through the principle of green chemistry.