The active monitoring of oxytocin research evidence (AMORE) platform

Oxytocin, an evolutionarily conserved neuropeptide, plays a crucial role in various physiological and behavioural processes, offering potential therapeutic benefits for several psychiatric and neurodevelopmental conditions. Despite its promise, oxytocin research has been marked by inconsistent results concerning its therapeutic applications and underlying mechanisms. Performing a systematic review and meta-analysis is a popular approach to shed light on mixed findings in a body of literature; however, they can become quickly outdated as new evidence becomes available. Given these challenges, research on the links between oxytocin and biobehavioural outcomes is ideally positioned for the adoption of 'living' meta-analyses, which allow for the continuous integration of new data and updated conclusions. Here we introduce the Active Monitoring of Oxytocin Research Evidence (AMORE) platform (https://amore-project.org), which is a hub that aggregates articles and materials associated with living meta-analyses for biobehavioural oxytocin research in humans. Developed through consensus among 24 expert researchers, a standardized framework was established that either requires or recommends practices ensuring transparency and rigor in living meta-analyses featured on the AMORE platform. Overall, AMORE has been designed to advance human oxytocin biobehavioural research by the timely integration of emerging evidence through transparent living meta-analyses. To date, two living meta-analysis projects at different stages of publication are hosted on AMORE, demonstrating the platform's practical application.

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Publication Details

Journal
Psychoneuroendocrinology
Published
2025-12-06
DOI
https://doi.org/10.1016/j.psyneuen.2025.107713
Citations
2
Primary Topic
Neuroendocrine regulation and behavior
Type
article
Field-Weighted Citation Impact
4.88
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article

The active monitoring of oxytocin research evidence (AMORE) platform

Alina M. Sartorius, Beate Ditzen, Marian J. Bakermans‐Kranenburg, Matthijs Moerkerke et al.
2 citations
Psychoneuroendocrinology
Neuroendocrine regulation and behavior
4.88
article

The active monitoring of oxytocin research evidence (AMORE) platform

Alina M. Sartorius, Beate Ditzen, Marian J. Bakermans‐Kranenburg, Matthijs Moerkerke, Nicole Nadine Lønfeldt, Christian Montag, Anna‐Rosa Cecilie Mora‐Jensen, Hidenori Yamasue, Daniel Quintana, Kaat Alaerts, Jennifer A. Bartz, Benjamin Becker, James Blair, Ekaterina Schneider, Dirk Scheele, Leehe Peled‐Avron, Jessica J. Connelly, Marilyn Horta, Tanya L. Procyshyn, Constantina Theofanopoulou, Natalie C. Ebner, Heemin Kang, Elizabeth A. Lawson, Ingebjørg Anjadatter Iversen
article en
2 citations

Abstract

Oxytocin, an evolutionarily conserved neuropeptide, plays a crucial role in various physiological and behavioural processes, offering potential therapeutic benefits for several psychiatric and neurodevelopmental conditions. Despite its promise, oxytocin research has been marked by inconsistent results concerning its therapeutic applications and underlying mechanisms. Performing a systematic review and meta-analysis is a popular approach to shed light on mixed findings in a body of literature; however, they can become quickly outdated as new evidence becomes available. Given these challenges, research on the links between oxytocin and biobehavioural outcomes is ideally positioned for the adoption of 'living' meta-analyses, which allow for the continuous integration of new data and updated conclusions. Here we introduce the Active Monitoring of Oxytocin Research Evidence (AMORE) platform (https://amore-project.org), which is a hub that aggregates articles and materials associated with living meta-analyses for biobehavioural oxytocin research in humans. Developed through consensus among 24 expert researchers, a standardized framework was established that either requires or recommends practices ensuring transparency and rigor in living meta-analyses featured on the AMORE platform. Overall, AMORE has been designed to advance human oxytocin biobehavioural research by the timely integration of emerging evidence through transparent living meta-analyses. To date, two living meta-analysis projects at different stages of publication are hosted on AMORE, demonstrating the platform's practical application.

PsychoneuroendocrinologyVol. 185
University of Copenhagen (DK), Oslo University Hospital (NO), Hamamatsu University (JP), Bar-Ilan University (IL), University of Oslo (NO), University of Zurich (CH), University of Macau (MO), University of Cambridge (GB), Mental Health Services (DK), Copenhagen University Hospital (DK), Moffitt Cancer Center (US), Hamamatsu University School of Medicine (JP), San Sebastián University (CL), Ghent University (BE), University of Florida (US), Massachusetts General Hospital (US), University College Copenhagen (DK), Neuroelectronics Research Flanders (BE), McGill University (CA), University of Virginia (US), Rockefeller University (US), University of Hong Kong (HK), Ruhr University Bochum (DE)
Openalex Percentile: Top 4%
Neuroendocrine regulation and behavior
4.88
DOIOpen Access PDFOpenAlex
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