A spectral method for multi-view subspace learning using the product of projections

Summary Multi-view data provides complementary information on the same set of observations, with multi-omics and multimodal sensor data being common examples. Analysing such data typically requires distinguishing between shared (joint) and unique (individual) signal subspaces from noisy, high-dimensional measurements. Despite many proposed methods, the conditions for reliably identifying joint and individual subspaces remain unclear. We rigorously quantify these conditions, which depend on the ratio of the signal rank to the ambient dimension, principal angles between true subspaces, and noise levels. Our approach characterizes how spectrum perturbations of the product of projection matrices, derived from each view’s estimated subspaces, affect subspace separation. Using these insights, we provide an easy-to-use and scalable estimation algorithm. In particular, we employ rotational bootstrap and random matrix theory to partition the observed spectrum into joint, individual, and noise subspaces. Diagnostic plots visualize this partitioning, providing practical and interpretable insights into the estimation performance. In simulations, our method estimates joint and individual subspaces more accurately than existing approaches. Applications to multi-omics data from colorectal cancer patients and nutrigenomic study of mice demonstrate improved performance in downstream predictive tasks.

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Publication Details

Journal
Biometrika
Published
2025-12-05
DOI
https://doi.org/10.1093/biomet/asaf088
Primary Topic
Single-cell and spatial transcriptomics
Type
article
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article

A spectral method for multi-view subspace learning using the product of projections

Renat Sergazinov, Armeen Taeb, Irina Gaynanova
Biometrika
Single-cell and spatial transcriptomics
article

A spectral method for multi-view subspace learning using the product of projections

Renat Sergazinov, Armeen Taeb, Irina Gaynanova
article en

Abstract

Summary Multi-view data provides complementary information on the same set of observations, with multi-omics and multimodal sensor data being common examples. Analysing such data typically requires distinguishing between shared (joint) and unique (individual) signal subspaces from noisy, high-dimensional measurements. Despite many proposed methods, the conditions for reliably identifying joint and individual subspaces remain unclear. We rigorously quantify these conditions, which depend on the ratio of the signal rank to the ambient dimension, principal angles between true subspaces, and noise levels. Our approach characterizes how spectrum perturbations of the product of projection matrices, derived from each view’s estimated subspaces, affect subspace separation. Using these insights, we provide an easy-to-use and scalable estimation algorithm. In particular, we employ rotational bootstrap and random matrix theory to partition the observed spectrum into joint, individual, and noise subspaces. Diagnostic plots visualize this partitioning, providing practical and interpretable insights into the estimation performance. In simulations, our method estimates joint and individual subspaces more accurately than existing approaches. Applications to multi-omics data from colorectal cancer patients and nutrigenomic study of mice demonstrate improved performance in downstream predictive tasks.

Biometrika
University of Washington (US), University of Michigan (US), Texas A&M University (US)
Openalex Percentile: Top 65%
Single-cell and spatial transcriptomics
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A spectral method for multi-view subspace learning using the product of projections — Renat Sergazinov, Armeen Taeb, et al. · Biometrika (2025) | TGRS Research Map | TGRS