Somatic alterations of genitourinary malignancy of Chinese population based on tumor NGS data
This study analyzed 321 tumor samples from 244 Chinese patients with genitourinary cancers using targeted NGS. Distinct mutational landscapes and PD-L1-associated genes were identified across bladder, renal, and prostate cancers. Comparative analysis with Western cohorts revealed population-specific genomic heterogeneity, supporting region-tailored precision oncology.
Authors
- Shuhua Zhao (ORCID: https://orcid.org/0000-0003-4698-4140)
- Xin Lu (ORCID: https://orcid.org/0009-0002-3882-2950)
- S. Cheng (ORCID: https://orcid.org/0000-0001-5079-402X)
- Jun Zhang
- Wei Chen (ORCID: https://orcid.org/0000-0002-6383-7540)
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-7543-8352)
- Yuan Shao
- Weiqing Ning (ORCID: https://orcid.org/0009-0006-9287-5008)
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Ruijin Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Gannan Medical University (CN)
- Changhai Hospital (CN)
- Beike Biotechnology (China) (CN)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.urolonc.2025.11.007
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00