Single Muscle Fiber Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis: An Exploratory Validation Study
The CaWFa effectively discriminates MHS from MHN muscle in response to halothane, offering a comparable sensitivity and specificity to the IVCT. The CaWFa shows promising potential as a minimally invasive alternative to IVCT for diagnosing MH susceptibility.
Authors
- Daniel P. Singh (ORCID: https://orcid.org/0000-0002-4868-2501)
- Bradley S. Launikonis (ORCID: https://orcid.org/0000-0003-0700-4867)
- Gail Wong (ORCID: https://orcid.org/0000-0001-6110-1882)
- Robyn Gillies (ORCID: https://orcid.org/0000-0002-5057-0349)
- Andrew R. Bjorksten
- Margaret Perry
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Queensland (AU)
- Children's Hospital at Westmead (AU)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1097/aln.0000000000005882
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00