Impact of <i>SPOP</i> Mutations on Clinical Outcomes in Metastatic Prostate Cancer
<i>SPOP</i> mutations were associated with longer OS despite the presence of aggressive clinical features. The distinct clinical and molecular features of <i>SPOP</i>-mutated PC support its consideration as a unique molecular subtype with prognostic implications.
Authors
- Alexandra Sokolova (ORCID: https://orcid.org/0000-0003-0821-6503)
- Michael Thomas Schweizer (ORCID: https://orcid.org/0000-0002-5510-0661)
- Jones T. Nauseef (ORCID: https://orcid.org/0000-0003-2302-4171)
- Laura Graham (ORCID: https://orcid.org/0000-0003-4371-572X)
- Amanda Pilling (ORCID: https://orcid.org/0000-0003-1034-2971)
- Vadim S. Koshkin (ORCID: https://orcid.org/0000-0003-2277-8668)
- Andrew J. Armstrong (ORCID: https://orcid.org/0000-0001-7012-1754)
- Clara Hwang (ORCID: https://orcid.org/0000-0002-0998-323X)
- Mehmet Asım Bilen (ORCID: https://orcid.org/0000-0003-4003-1103)
- Yousef Zakharia (ORCID: https://orcid.org/0000-0001-9480-2626)
- Rohan Garje (ORCID: https://orcid.org/0000-0002-7244-5602)
- Pedro Coelho Barata (ORCID: https://orcid.org/0000-0002-8890-2951)
- Deepak Kilari (ORCID: https://orcid.org/0000-0002-6999-1901)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Shabi Haider (ORCID: https://orcid.org/0000-0001-8132-8646)
- Frank C. Cackowski (ORCID: https://orcid.org/0000-0002-0075-3745)
- Ruben Raychaudhuri (ORCID: https://orcid.org/0000-0001-6587-4954)
- Shoshana Rothstein
- Adanma Ayanambakkam (ORCID: https://orcid.org/0000-0001-8070-7927)
- Abhishek Tripathi (ORCID: https://orcid.org/0000-0002-5198-0673)
- Erica Chin
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- Zachery R. Reichert (ORCID: https://orcid.org/0000-0003-0356-8796)
- Joseph J. Park (ORCID: https://orcid.org/0000-0003-1311-5416)
- Yao Ye (ORCID: https://orcid.org/0000-0002-2187-0211)
- Nicholas Henderson (ORCID: https://orcid.org/0000-0003-3184-0945)
- Kyra Yamamoto
Institutions
- Baptist Hospital of Miami (US)
- Emory University (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Wayne State University (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- Cornell University (US)
- University of Michigan (US)
- Henry Ford Hospital (US)
- University of California San Diego (US)
- Fred Hutch Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Baptist Health South Florida (US)
- City of Hope (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- Mayo Clinic Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Weill Cornell Medicine (US)
- University of Oklahoma Health Sciences Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/po-25-00590
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52