Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity: a multicentre, prospective observational study
One in 4 PSC patients experience moderate-severe pruritus, with greater symptom intensity in those with advanced disease. Our dataset is able to serve as a reference tool to aid future interventional study design, with regard to anti-pruritus therapies in PSC.
Authors
- James Ferguson (ORCID: https://orcid.org/0000-0002-2529-0409)
- Penelope Rogers
- Emma Louise Culver (ORCID: https://orcid.org/0000-0001-9644-8392)
- Andrea Ribeiro
- Megan McLaughlin (ORCID: https://orcid.org/0000-0002-9259-2984)
- Linda Casillas
- Martine Walmsley (ORCID: https://orcid.org/0000-0003-4622-5590)
- Sumanta Mukherjee (ORCID: https://orcid.org/0000-0001-7812-1257)
- Palak Trivedi (ORCID: https://orcid.org/0000-0002-4009-8087)
- Andreas Emanuel Kremer (ORCID: https://orcid.org/0000-0002-9263-948X)
- Usha Gungabissoon (ORCID: https://orcid.org/0000-0002-2040-1763)
- Nasir Hussain (ORCID: https://orcid.org/0000-0002-8547-8585)
- Kaitlin Hagan
- Khushpreet Bhandal
- R Motta (ORCID: https://orcid.org/0009-0001-6252-6708)
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Zurich (CH)
- National Institute for Health and Care Research (GB)
- University Hospital of Zurich (CH)
- GlaxoSmithKline (United States) (US)
- Oxford BioMedica (United Kingdom) (GB)
- Oxford University Hospitals NHS Trust (GB)
- GlaxoSmithKline (Spain) (ES)
- Centre for Inflammation Research (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Hepatology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1097/hep.0000000000001634
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00