Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are <i>APOE</i> ε4 Carriers
<i>APOE</i> ε4 defines a PD subtype characterized by greater motor impairment, reduced CSF Aβ42/Aβ40, and distinct FC abnormalities since the onset. An early amyloid-mediated network disruption thus emerges as the potential biological signature of ε4 carriers. Although limited by single-center and cross-sectional design, this study supports <i>APOE</i> ε4 as a stratification marker for early diagnostic and therapeutic strategies in PD.
Authors
- Sergio Bernardini (ORCID: https://orcid.org/0000-0003-1984-6834)
- Francesca Di Giuliano (ORCID: https://orcid.org/0000-0002-6067-183X)
- Davide Mascioli (ORCID: https://orcid.org/0009-0009-0292-1640)
- Clara Simonetta (ORCID: https://orcid.org/0009-0007-3269-8684)
- Mariangela Pierantozzi (ORCID: https://orcid.org/0000-0002-4507-4666)
- Tommaso Schirinzi (ORCID: https://orcid.org/0000-0002-2517-6278)
- Matteo Conti (ORCID: https://orcid.org/0000-0002-1579-9674)
- Jacopo Bissacco (ORCID: https://orcid.org/0009-0003-2350-4121)
- Valerio Ferrari
- Enrica Marchionni (ORCID: https://orcid.org/0000-0002-0341-6461)
- Alessandro Stefani (ORCID: https://orcid.org/0000-0002-1806-8922)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Federico Carparelli
- Silvio Bagetta
Institutions
- University of Rome Tor Vergata (IT)
- Policlinico Tor Vergata (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214449
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17