Impact of Cerebral Microbleeds on Tau-Associated Cognitive and Structural Decline
In the non-CMB group, tau burden was strongly associated with cognitive decline and cortical atrophy. By contrast, the CMB group exhibited greater CSVD burden and pronounced neurodegeneration not explained by tau, suggesting that additional mechanisms such as CSVD related to cerebral amyloid angiopathy or neuroinflammation may contribute to disease progression in this group.
Authors
- Kayeong Tak
- Young Noh (ORCID: https://orcid.org/0000-0002-9633-3314)
- Jaelim Cho (ORCID: https://orcid.org/0000-0002-4524-0310)
- Shin‐Eui Park (ORCID: https://orcid.org/0000-0002-4718-8691)
- Kee Hyung Park (ORCID: https://orcid.org/0000-0001-6847-6679)
- Ha‐Eun Seo (ORCID: https://orcid.org/0000-0003-4452-0908)
- Young Hee Jung (ORCID: https://orcid.org/0000-0002-8945-2200)
- Sang‐Yoon Lee (ORCID: https://orcid.org/0000-0002-6029-8553)
- Woo‐Ram Kim (ORCID: https://orcid.org/0000-0003-1361-4426)
Institutions
- Gachon University (KR)
- Hallym University (KR)
- Yonsei University (KR)
- Sacred Heart Hospital (NG)
- Gachon University Gil Medical Center (KR)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214453
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00