Postoperative Pain Management in Patients with Lower-Extremity Amputations: A Single-Institution Retrospective Analysis of the Effectiveness of Non-opioid Analgesics in Reduction of Opioid Use

Among patients recovering from lower extremity amputation during inpatient rehabilitation, gabapentin use was significantly associated with lower opioid requirements, with pregabalin demonstrating a similar pattern. Incorporating these agents into multimodal analgesic regimens may help optimize postoperative pain control and limit opioid exposure. Further research is warranted to explore the role of additional non-opioid options in this setting.