Zinc-Related Proteasome Variants in Type 1 Diabetes: An in Silico-Guided Case-Control Study
The <i>PSMC6</i> rs2295825 SNP may confer protection against T1DM. The <i>PSMC6</i> rs2295825, <i>PSMB9</i> rs17587, <i>PSMA6</i> rs1048990, and <i>PSMD3</i> rs3087852 SNPs appear to influence lipid metabolism and diabetic microvascular complications.
Authors
- Cristine Dieter (ORCID: https://orcid.org/0000-0003-2765-930X)
- Daisy Crispim (ORCID: https://orcid.org/0000-0001-5095-9269)
- Luís Henrique Santos Canani (ORCID: https://orcid.org/0000-0002-1813-4491)
- Chih‐Hao Lu (ORCID: https://orcid.org/0000-0002-8363-6244)
- Taís Silveira Assmann (ORCID: https://orcid.org/0000-0001-9114-8243)
- Felipe Mateus Pellenz (ORCID: https://orcid.org/0000-0002-7829-9407)
- Eliandra Girardi (ORCID: https://orcid.org/0000-0003-4485-0202)
- Raif Gregorio Nasre‐Nasser (ORCID: https://orcid.org/0000-0002-8350-1008)
- Alexandre Eduardo Franzin Vieira (ORCID: https://orcid.org/0009-0000-4901-5199)
- Luciane Moretto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- National Yang Ming Chiao Tung University (TW)
- Hospital de Clínicas de Porto Alegre (BR)
- Universidade La Salle (BR)
- Universidade do Vale do Rio dos Sinos (BR)
Publication Details
- Journal
- Metabolites
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3390/metabo15120772
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital de Clínicas de Porto Alegre
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Fundação Instituto de Pesquisas Econômicas
- Pakistan Atomic Energy Commission