Single-cell transcriptome analysis reveals regulatory programs of prognosis-associated RNA binding proteins during LIHC development

RBPs display single-cell-level heterogeneity and are associated with pathways relevant to HCC progression. HDGF is identified as a candidate oncogenic RBP based on in vitro phenotypes and correlative splicing analyses. These findings highlight the potential of RBPs, including HDGF, as candidates for further mechanistic and therapeutic exploration in HCC.

Authors

Hanfei Huang (ORCID: https://orcid.org/0000-0002-0852-9596)
Zhong Zeng (ORCID: https://orcid.org/0000-0001-6348-2009)
En-di Zhang
Jin Li (ORCID: https://orcid.org/0000-0002-7957-1476)
Zhuo Cheng (ORCID: https://orcid.org/0000-0001-7807-2571)
Chenxuan Li (ORCID: https://orcid.org/0000-0002-6110-0596)

Institutions

Kunming Medical University (CN)
First Affiliated Hospital of Kunming Medical University (CN)

Publication Details

Journal: Cancer Cell International
Published: 2025-12-05
DOI: https://doi.org/10.1186/s12935-025-04088-z
Primary Topic: Fibroblast Growth Factor Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Single-cell transcriptome analysis reveals regulatory programs of prognosis-associated RNA binding proteins during LIHC development

Hanfei Huang, Zhong Zeng, En-di Zhang, Jin Li et al.

Dec 5, 2025

Cancer Cell International

Fibroblast Growth Factor Research

article

Single-cell transcriptome analysis reveals regulatory programs of prognosis-associated RNA binding proteins during LIHC development

Hanfei Huang, Zhong Zeng, En-di Zhang, Jin Li, Zhuo Cheng, Chenxuan Li

December 5, 2025article en

Abstract

RBPs display single-cell-level heterogeneity and are associated with pathways relevant to HCC progression. HDGF is identified as a candidate oncogenic RBP based on in vitro phenotypes and correlative splicing analyses. These findings highlight the potential of RBPs, including HDGF, as candidates for further mechanistic and therapeutic exploration in HCC.

Cancer Cell InternationalVol. 26(1)

Kunming Medical University (CN), First Affiliated Hospital of Kunming Medical University (CN)

Openalex Percentile: Top 65%

Fibroblast Growth Factor Research

DOI Open Access PDF OpenAlex

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Single-cell transcriptome analysis reveals regulatory programs of prognosis-associated RNA binding proteins during LIHC development — Hanfei Huang, Zhong Zeng, et al. · Cancer Cell International (2025) | TGRS Research Map | TGRS