Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies
This study provide new insights into the molecular basis of BC and support the idea of targeting TGFβ-1 and CXCR4 together for therapy. The above findings lay the foundation for future in vitro and in vivo experiments aimed at demonstrating that inhibition of both factors would be a viable strategy to improve the therapeutic outcome in BC.
Authors
- Abdullah Almilaibary (ORCID: https://orcid.org/0000-0002-4933-1711)
- Burhan Ul Haq (ORCID: https://orcid.org/0000-0003-3539-2035)
- Asma Jan
- Hina Qayoom (ORCID: https://orcid.org/0000-0001-8484-3424)
- Bader Alshehri (ORCID: https://orcid.org/0000-0002-2847-0106)
- Fuzail Ahmad (ORCID: https://orcid.org/0000-0002-1189-2206)
- Manzoor Ahmad Mir (ORCID: https://orcid.org/0000-0003-3297-1402)
- Mohammad Abdullah Aljasir (ORCID: https://orcid.org/0000-0002-3708-9200)
- Irshad Ahmad (ORCID: https://orcid.org/0000-0003-0077-3065)
- Shazia Sofi (ORCID: https://orcid.org/0000-0002-6895-3487)
Institutions
- Alfaisal University (SA)
- University of Kashmir (IN)
- Qassim University (SA)
- Majmaah University (SA)
- Al Baha University (SA)
- King Khalid University (SA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1371/journal.pone.0323665
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00