In-hospital survival of adults with HIV-associated cryptococcal meningitis in Tanzania: A retrospective comparison of amphotericin B-based regimen and fluconazole monotherapy
CM remains a leading opportunistic infection causing high mortality among PHIV, with most patients managed using fluconazole monotherapy. In-hospital survival was significantly higher with amphotericin B-based regimens, highlighting the need to align practice with guideline recommendations. Further qualitative research is warranted to explore barriers to implementing recommended CM treatment.
Authors
- Alphonce Ignace Marealle (ORCID: https://orcid.org/0000-0002-9864-5469)
- Ritah Francis Mutagonda (ORCID: https://orcid.org/0000-0001-8963-4920)
- George Musiba (ORCID: https://orcid.org/0000-0002-8999-7307)
- Manase E Kilonzi (ORCID: https://orcid.org/0000-0002-5355-8353)
- Jaafar I. Mohamed
- Mlela Msongela
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- Muhimbili National Hospital (TZ)
- Singer (United States) (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1371/journal.pone.0332786
- Citations
- 1
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35