Mesenchymal stem cell-derived exosomes ameliorate gentamicin-induced vestibular hair cell injury by regulating the SNARE pathway and enhancing autophagy
hucMSC-EXOs delivered via intratympanic injection effectively target vestibular sensory epithelia, significantly suppressing gentamicin-induced balance dysfunction and high-frequency hearing loss, with superior efficacy in partial indicators (e.g., movement speed, saccular hair cell repair) compared to dexamethasone. hucMSC-EXOs exert protective effects through a dual mechanism of "anti-apoptosis and pro-autophagy," providing a novel therapeutic strategy for vestibular hair cell injury.
Authors
- Ruokang Han
- Lin Shi (ORCID: https://orcid.org/0000-0003-2070-6564)
- Yanan Wu (ORCID: https://orcid.org/0000-0003-3240-6278)
- Chuan Qin (ORCID: https://orcid.org/0000-0002-6261-1232)
- Jing Wang (ORCID: https://orcid.org/0000-0001-9981-5530)
- Ning Yu (ORCID: https://orcid.org/0000-0003-4972-4010)
- Guisheng Qi
- Liang Wang (ORCID: https://orcid.org/0009-0009-7673-7272)
Institutions
- Dalian Medical University (CN)
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13287-025-04819-z
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46