Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification

Diabetic retinopathy (DR) stands as a leading cause of global blindness. Early identification and prompt treatment are essential to prevent vision impairment caused by DR. Manual screening of retinal fundus images is challenging and time-consuming. Additionally, in low-income countries, there is a significant gap between the number of DR patients and ophthalmologists. Currently, machine learning (ML) and deep learning (DL) are becoming a viable alternative to traditional DR screening techniques. However, DL suffers a major limitation in resource-constrained devices because of its large model size and substantial computational demands. Knowledge distillation is a prominent technique for creating lightweight models, effectively transferring knowledge from a larger, complex model to a smaller, more efficient one without significant loss in performance. Therefore, in this research, a lightweight student model is proposed, which follows the MobileNet architectural design by utilizing depthwise separable convolutions. This design ensures efficient performance suitable for edge device deployment. For binary classification, our proposed model achieved an accuracy, precision, and recall of 98.38% on the APTOS 2019 dataset, whereas the proposed model achieved an accuracy of 93.03% for ternary classification on APTOS 2019.

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Publication Details

Journal
Scientific Reports
Published
2025-12-05
DOI
https://doi.org/10.1038/s41598-025-30893-7
Primary Topic
Retinal Imaging and Analysis
Type
article
Field-Weighted Citation Impact
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article

Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification

Girum W. Gessesse, Taye Girma Debelee, Hasset Tamirat Molla, Yehualashet Megersa Ayano et al.
Scientific Reports
Retinal Imaging and Analysis
article

Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification

Girum W. Gessesse, Taye Girma Debelee, Hasset Tamirat Molla, Yehualashet Megersa Ayano, Fitsum Mesfin Dejene, Degaga Wolde Feyisa, Zelalem Chimdesa Merga, Hiwot Taye Mekonnen, Destaw Mulie
article en

Abstract

Diabetic retinopathy (DR) stands as a leading cause of global blindness. Early identification and prompt treatment are essential to prevent vision impairment caused by DR. Manual screening of retinal fundus images is challenging and time-consuming. Additionally, in low-income countries, there is a significant gap between the number of DR patients and ophthalmologists. Currently, machine learning (ML) and deep learning (DL) are becoming a viable alternative to traditional DR screening techniques. However, DL suffers a major limitation in resource-constrained devices because of its large model size and substantial computational demands. Knowledge distillation is a prominent technique for creating lightweight models, effectively transferring knowledge from a larger, complex model to a smaller, more efficient one without significant loss in performance. Therefore, in this research, a lightweight student model is proposed, which follows the MobileNet architectural design by utilizing depthwise separable convolutions. This design ensures efficient performance suitable for edge device deployment. For binary classification, our proposed model achieved an accuracy, precision, and recall of 98.38% on the APTOS 2019 dataset, whereas the proposed model achieved an accuracy of 93.03% for ternary classification on APTOS 2019.

Scientific ReportsVol. 16(1)
Ethiopian Public Health Institute (ET), Addis Ababa Science and Technology University (ET), St. Paul's Hospital Millennium Medical College (ET), Addis Ababa University (ET)
Openalex Percentile: Top 46%
Retinal Imaging and Analysis
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