Food deprivation enhances disease resistance: Underlying mechanisms in oysters confronted with pacific oyster mortality syndrome
Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An <i>ad libitum</i> diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (<i>ad libitum</i> vs. starvation) affects interactions between the oyster <i>Magallana gigas</i> and the herpesvirus OsHV-1 μVar initiating the panzootic Pacific oyster mortality syndrome (POMS). We found that starvation reduced oyster susceptibility to POMS. Through a comparative integrative-omics approach, we showed that (1) starvation induces metabolic rate depression, which may limit viral replication by reducing the availability of cellular energy that viruses can hijack, and (2) enhances autophagy and antiviral responses, thereby improving viral control. These results underscore the importance of nutritional status in shaping viral disease outcomes and may inform management strategies in aquaculture systems.
Authors
- Séverine Henry (ORCID: https://orcid.org/0000-0002-1196-1507)
- Lionel Dégremont (ORCID: https://orcid.org/0000-0001-6759-6791)
- Arnaud Lagorce
- Andrei Turtoï (ORCID: https://orcid.org/0000-0003-3813-6635)
- Julien de Lorgeril (ORCID: https://orcid.org/0000-0002-6400-5455)
- A. Valdivieso (ORCID: https://orcid.org/0000-0002-6653-1491)
- Guillaume Mitta (ORCID: https://orcid.org/0000-0003-1188-1467)
- Charlotte Corporeau (ORCID: https://orcid.org/0000-0003-1187-358X)
- Ève Toulza (ORCID: https://orcid.org/0000-0003-2049-2279)
- Cristián J. Monaco (ORCID: https://orcid.org/0000-0003-4057-5290)
- Juliette Pouzadoux (ORCID: https://orcid.org/0009-0000-6769-6290)
- Jean‐François Allienne (ORCID: https://orcid.org/0000-0001-6343-308X)
- Océane Romatif (ORCID: https://orcid.org/0009-0004-5182-9772)
- Bruno Petton (ORCID: https://orcid.org/0000-0002-4169-2811)
- Fabrice Pernet (ORCID: https://orcid.org/0000-0001-8886-0184)
- Léo Duperret (ORCID: https://orcid.org/0009-0009-7102-7941)
- Benjamín Morga (ORCID: https://orcid.org/0000-0002-3196-4537)
- Nicole Faury
- Jérémie Vidal‐Dupiol (ORCID: https://orcid.org/0000-0002-0577-2953)
- Gaëlle Courtay
Institutions
- University of New Caledonia (NC)
- Centre National de la Recherche Scientifique (FR)
- Université de Perpignan (FR)
- Ifremer (FR)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- Université de Montpellier (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Institut Louis Malardé (PF)
- Institut de Recherche pour le Développement (FR)
- University of French Polynesia (PF)
Publication Details
- Journal
- iScience
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.isci.2025.114333
- Primary Topic
- Marine Bivalve and Aquaculture Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00