Development of a comprehensive cardiovascular disease genetic risk assessment test
A genome-sequencing-based CVD genetic risk assessment test can provide comprehensive genetic disease and genetic risk information to patients with CVD. The semiautomated and limited interpretation burden suggest that this testing approach can be scaled to support population-level initiatives in phenotypically enriched populations.
Authors
- Josh Lowry (ORCID: https://orcid.org/0000-0003-3671-469X)
- Stetson Thacker (ORCID: https://orcid.org/0000-0001-6050-409X)
- Ryan J. Taft (ORCID: https://orcid.org/0000-0003-4538-3343)
- Julie P. Taylor (ORCID: https://orcid.org/0000-0003-1819-3640)
- Elliott H. Margulies
- Andrew Walker (ORCID: https://orcid.org/0000-0002-7890-1779)
- Tasha Kalista
- David E. Lanfear (ORCID: https://orcid.org/0000-0001-6471-1483)
- Laura M. Amendola (ORCID: https://orcid.org/0000-0002-5506-6168)
- Subramanian S. Ajay
- Revathi Rajkumar
- Felipe Mullen
- Mauro Longoni (ORCID: https://orcid.org/0000-0001-9600-1160)
- Alison J. Coffey (ORCID: https://orcid.org/0000-0002-1338-8513)
- Katie Golden‐Grant
- John W. Belmont (ORCID: https://orcid.org/0000-0001-7409-3578)
- Alka Malhotra (ORCID: https://orcid.org/0000-0003-1174-688X)
- Carolyn M. Brown (ORCID: https://orcid.org/0000-0003-4587-0002)
- James Avecilla
- Becky Milewski
- Samuel P. Strom (ORCID: https://orcid.org/0000-0003-3254-7564)
- Rueben Hejja
- Damon Hostin
- Phillip Medrano
- Keisha Robinson
- Denise Perry
- Aditi Chawla
- Adriana Huertez-Vasquez
- Jennifer A. Lee (ORCID: https://orcid.org/0000-0003-2890-7483)
- Akanchha Kesari
Institutions
- Henry Ford Health System (US)
- Illumina (United States) (US)
- Baylor College of Medicine (US)
- Greenwood Genetic Center (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.gimo.2025.103482
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00