Preoperative Treatment with Bisphosphonates Does Not Change the Thermal Response of Focused Ultrasound Thalamotomy
No significant differences were found in sonication response parameters between the bisphosphonate-treated and untreated low-SDR groups, whereas mid- and high-SDR groups had significantly reduced sonication energy and time to produce greater heat. These findings show that while bisphosphonates are an established way of raising bone density in osteoporosis, pre-treatment with bisphosphonates does not shift the sonication response from that of a low SDR to a mid-range SDR. Additionally, other factors besides just skull density likely determine the thermal response to sonication.
Authors
- Hong Shi (ORCID: https://orcid.org/0000-0002-0182-8729)
- Matthew C. Henn (ORCID: https://orcid.org/0000-0002-1561-7009)
- Daniel R. Cleary (ORCID: https://orcid.org/0000-0001-7112-4519)
- Nemanja Useinovic (ORCID: https://orcid.org/0000-0003-2788-7441)
- Joan Cahill (ORCID: https://orcid.org/0000-0001-6944-744X)
- Beck Shafie (ORCID: https://orcid.org/0009-0006-3539-120X)
- M. Patricia Joyce (ORCID: https://orcid.org/0009-0009-0596-1488)
- Haley D. Smith (ORCID: https://orcid.org/0009-0003-1807-1835)
- Ahmed M. Raslan
- Tim Valuev
- Christian G. Lopez-Ramos
Institutions
- Oregon Health & Science University (US)
- Portland VA Medical Center (US)
- Neurological Surgery (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Stereotactic and Functional Neurosurgery
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1159/000549833
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00