FAM189A2 activates Hippo signaling pathway by abrogating WWP2-mediated LATS1 ubiquitination, to inhibit the glycolysis and proliferation processes of lung adenocarcinoma
FAM189A2 can be considered as a potential diagnostic and prognostic marker associated with LUAD, and suppresses the proliferation and glycolytic metabolism of LUAD cells via WWP2-LATS1-YAP signaling, which will provide a corresponding theoretical foundation for the development of small molecule inhibitors.
Authors
- Xuezhu Rong (ORCID: https://orcid.org/0000-0001-6623-5927)
- Bingyu Chen (ORCID: https://orcid.org/0009-0007-6589-7460)
- Yuekang Hou
- Xuyong Lin
- Lin Fu (ORCID: https://orcid.org/0000-0003-0496-5793)
- Yan Song (ORCID: https://orcid.org/0000-0002-5955-0205)
- Yuheng Feng
- Qiang Han
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- First Hospital of China Medical University (CN)
- Chongqing Public Health Medical Center (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12967-025-07526-8
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15