A Longitudinal Investigation of Prediabetes, Diabetes, <scp>HbA1c</scp> and Cognitive Trajectories Among Cognitively Unimpaired Individuals
The results suggest that prediabetes and diabetes significantly shorten the timeframe before a potentially clinically noticeable change in global and domain-specific cognition is reached. Thus, lifestyle modification to reverse prediabetes and prevent diabetes could potentially reduce the rate of cognitive decline in aging populations. The findings differed by sex (i.e., the effect of diabetes on decline in global cognition, attention and visuospatial domains was more pronounced in women than men).
Authors
- Elmar Aigner (ORCID: https://orcid.org/0000-0003-0310-0536)
- Bernhard Iglseder (ORCID: https://orcid.org/0000-0002-6132-8670)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jeremy A. Syrjanen (ORCID: https://orcid.org/0000-0001-5990-8206)
- Maria Vassilaki (ORCID: https://orcid.org/0000-0001-8328-136X)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Walter K. Kremers (ORCID: https://orcid.org/0000-0001-5714-3473)
- Yonas E. Geda (ORCID: https://orcid.org/0000-0003-1187-7230)
- Anna Pink
- Janina Krell‐Roesch (ORCID: https://orcid.org/0000-0003-4011-9842)
- Susan B. Racette (ORCID: https://orcid.org/0000-0002-6932-1887)
- Ronald Petersen (ORCID: https://orcid.org/0009-0006-8296-6416)
Institutions
- Karlsruhe Institute of Technology (DE)
- Barrow Neurological Institute (US)
- Mayo Clinic (US)
- Paracelsus Medical University (AT)
- Mayo Clinic in Florida (US)
- Arizona State University (US)
Publication Details
- Journal
- Journal of the American Geriatrics Society
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1111/jgs.70231
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94