Causal Relationships Between Neuropathic Pain and Alzheimer’s Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy
This study provides the first evidence that DN may exert a protective effect against AD by regulating the aforementioned tissue-specific genes and associated pathways. This finding challenges the conventional understanding that chronic pain exacerbates AD and offers novel potential targets for developing therapeutic strategies. However, due to population limitations in the study, further experimental validation remains necessary.
Authors
- Kejia Wang (ORCID: https://orcid.org/0009-0003-4855-6382)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6509-2052)
- Huifang Shang (ORCID: https://orcid.org/0000-0003-0947-1151)
- Junyi Zheng (ORCID: https://orcid.org/0009-0006-5520-7078)
- Xiaoping Lin (ORCID: https://orcid.org/0000-0001-9489-3169)
- Di Liu (ORCID: https://orcid.org/0000-0003-3693-2726)
- Xiao Li (ORCID: https://orcid.org/0000-0001-9504-605X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jpr.s554433
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health