Therapeutic potential of nerinetide in acute ischemic stroke: a comprehensive systematic review and meta-analysis
Nerinetide may slightly reduce mortality in AIS, particularly among patients not treated with alteplase. Although functional outcomes did not significantly improve, its favorable safety profile and potential neuroprotective effect support further investigation in larger clinical trials.
Authors
- Muhammad Yasir Zahoor (ORCID: https://orcid.org/0000-0001-6055-4812)
- Sushil Suthar
- Shilpa Kumari (ORCID: https://orcid.org/0000-0002-6009-8631)
- Reeja Nasir (ORCID: https://orcid.org/0009-0000-4138-5718)
- Anying Bai (ORCID: https://orcid.org/0000-0002-3121-1228)
- Vikash Kumar (ORCID: https://orcid.org/0000-0002-0058-2421)
- FNU Simran (ORCID: https://orcid.org/0000-0002-9955-2942)
- Aayush Chaulagain (ORCID: https://orcid.org/0009-0008-0010-6071)
- Rimsha Zameer
- Taimour khan ghori
- F. N. U. Geeta
- Laiba Noorislam
- Khadija Humayun Hilaly
Institutions
- Jinnah Postgraduate Medical Center (PK)
- Karachi Medical and Dental College (PK)
- Patan Academy of Health Sciences (NP)
- Pakistan Health Research Council (PK)
- Liaquat National Hospital (PK)
- Dar Al-Shifa Hospital (PS)
- Civil Hospital Karachi (PK)
- Chandka Medical College (PK)
- Aga Khan Hospital Dar es Salaam (TZ)
- University Hospital Limerick (IE)
- Shaheed Mohtarma Benazir Bhutto Medical University (PK)
- National University of Medical Sciences (PK)
- Civil Service Hospital (NP)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1097/ms9.0000000000004454
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00