Fibrillarin Contributes to the Oncogenic Characteristics of Colorectal Cancer Cells and Reduces Sensitivity to 5-Fluorouracil
Our study identifies FBL as a potential contributor to colorectal cancer progression, with elevated expression associated particularly with metastatic disease. By demonstrating that FBL expression is elevated in patient-derived metastatic tissues and functionally promotes migration, invasion, and tumor growth, our findings expand the role of ribosome biogenesis factors beyond protein synthesis. The observed suppression of key oncogenic pathways and CREB phosphorylation upon FBL inhibition suggests that FBL integrates ribosomal regulation with cancer cell signaling. These insights open new avenues for targeting nucleolar activity in advanced CRC and highlight FBL as a potential biomarker and therapeutic target in metastatic disease.
Authors
- Mounira Chalabi‐Dchar (ORCID: https://orcid.org/0000-0002-4539-589X)
- Charles Dumontet (ORCID: https://orcid.org/0000-0003-1875-134X)
- Jean‐Jacques Diaz (ORCID: https://orcid.org/0000-0002-7914-4319)
- Ting Wu (ORCID: https://orcid.org/0009-0002-4931-2251)
- Sabine Beaumel
- Tanguy Fenouil (ORCID: https://orcid.org/0000-0002-2747-763X)
- Hichem C. Mertani (ORCID: https://orcid.org/0000-0002-5958-6662)
- Lucie Arnould
- Marie Alexandra Albaret (ORCID: https://orcid.org/0000-0003-3374-5298)
- Virginie Marcel (ORCID: https://orcid.org/0000-0002-9557-8221)
- Eliézer Aïmontché
- Wei Xiong (ORCID: https://orcid.org/0000-0003-1635-8173)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Southwest Medical University (CN)
- Hospices Civils de Lyon (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
Publication Details
- Journal
- Cancers
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3390/cancers17243900
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00