Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue
There is a paucity of data regarding defects in insulin signaling in insulin-resistant human white adipose tissue (WAT). The tether containing a UBX domain for GLUT4 (TUG) protein, which retains GLUT4 vesicles, was increased in WAT of participants with greater insulin resistance in three different cohorts with obesity. Components of the TUG regulatory signaling pathway were differentially expressed between participants with greater insulin resistance and those with greater insulin sensitivity. TUG may provide an important pharmacologic target in the treatment or prevention of metabolic dysfunction in patients with obesity.
Authors
- Aldo Jongejan (ORCID: https://orcid.org/0000-0002-8948-2549)
- Daniel F. Vatner (ORCID: https://orcid.org/0000-0003-2073-0273)
- Steven R. Shuken (ORCID: https://orcid.org/0000-0002-2782-2165)
- Jordan W. Strober (ORCID: https://orcid.org/0000-0001-8274-3956)
- Sonia Caprio (ORCID: https://orcid.org/0000-0002-7523-5053)
- João A. Paulo (ORCID: https://orcid.org/0000-0002-4291-413X)
- Aaron L. Slusher (ORCID: https://orcid.org/0000-0003-2082-4827)
- Mireille J. Serlie (ORCID: https://orcid.org/0000-0002-8666-3379)
- Nicola Santoro (ORCID: https://orcid.org/0000-0001-6437-4173)
- Jonathan S. Bogan (ORCID: https://orcid.org/0000-0001-6463-8466)
- Elena Tarabra (ORCID: https://orcid.org/0000-0003-4414-9037)
- Steven P. Gygi (ORCID: https://orcid.org/0000-0001-7626-0034)
- Daeun Sung
- Brandon M. Gassaway (ORCID: https://orcid.org/0000-0002-6102-2356)
- Kasper W. ter Horst (ORCID: https://orcid.org/0000-0002-0502-4023)
Institutions
- Brigham Young University (US)
- Harvard University (US)
- Veterans Health Administration (US)
- Yale University (US)
- Department of Veterans Affairs (AU)
- Amsterdam University Medical Centers (NL)
- Harvard Stem Cell Institute (US)
- University of Amsterdam (NL)
Publication Details
- Journal
- Diabetes
- Published
- 2025-12-05
- DOI
- https://doi.org/10.2337/db25-0488
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00