Transcriptomic insights into nerve growth factor–associated appositional bone formation in the reparative zone in osteonecrosis of the femoral head

These findings indicate that the reparative zone exhibiting appositional bone formation shows transcriptional activation of bone formation, accompanied by increased NGF expression. NGF may be involved in the molecular mechanisms underlying appositional bone formation in osteonecrosis of the femoral head, and serve as a potential regulator of this process.