Photoredox-Cobaloxime Catalysis [4 + 2] Annulation of Enamines with Alkynes for the Synthesis of Naphthylamine Derivatives
Herein, we present a strategy for the visible light-driven oxidative [4 + 2] annulation of enamines with alkynes to synthesize naphthylamine derivatives at room temperature under external-oxidant-free conditions. This protocol avoids the use of high temperatures, multistep reactions, and stoichiometric oxidants in the synthesis of naphthylamines, and it exhibits broad substrate compatibility, with high atom- and step-economy. Furthermore, this transformation also proceeds efficiently under natural sunlight irradiation.
Authors
- Xiu‐Long Yang (ORCID: https://orcid.org/0000-0003-3933-7738)
- Xiaoying Niu (ORCID: https://orcid.org/0000-0001-6779-2602)
- Qingyuan Meng (ORCID: https://orcid.org/0000-0002-2611-4271)
- Qiong Liu (ORCID: https://orcid.org/0000-0002-6958-3502)
- Haoyuan Li (ORCID: https://orcid.org/0000-0002-2469-5842)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Hebei University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1021/acs.joc.5c02421
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00