The Outcome of Autologous Platelet-Rich Fibrin Membrane in Failed Distal Hypospadias Repair

Objective: Failed distal hypospadias repair is considered a challenge due to the defi cient scarred local penile tissue for tubularization and neourethral coverage in tubular ized incised plate (TIP) repair and the high complications rate. To assess the additive effect of autologous platelet-rich fibrin (PRF) membrane neourethral coverage layer on failed distal hypospadias TIP repair outcomes. Methods: A total of 66 recurrent distal hypospadias patients who were suitable for TIP repair were divided into group A: 32 patients in whom a local penile dartos flap layer was used and group B: 34 patients in whom an autologous PRF membrane was used. All patients were followed up for 6-12 months postoperatively for the presence of any complications. Results: The reoperation rate in the Dartos group was more than twice that observed in the PRF group (28.1% vs. 11.8%; P = .11). Similarly, the rate of meatal stenosis (12.5% vs. 2.9%; P = .18), infection (15.6% vs. 8.8%; P = .46), and dehiscence (3.1% vs. 2.9%; P = 1.00) were all higher in the Dartos group. Urethrocutaneous fistula was reported in 7 patients, with 6 (18.75%) in group A and 1 (2.9%) in group B, showing a statistically significant difference (P < .05). Conclusion: The autologous PRF membrane could be an effective neourethral cover age layer in comparison to local dartos flap in decreasing complications rate post failed distal hypospadias TIP repair. Cite this article as: Abdelhalim KM, Abdelgawad E, Kadry AM, Bakr M, Abdelwahab H. The outcome of autologous platelet-rich fibrin membrane in failed distal hypospadias repair. Urol Res Pract. 2025;51(5):189-195.