Total Synthesis of (+)-Norsecurinamine B

Norsecurinamine B represents the first example of an NH-bridged dimeric <i>Securinega</i> alkaloid, in which two norsecurinine monomers are joined through an amine linker at their <i>endo</i> faces. However, the <i>exo</i> face of norsecurinine is intrinsically favored for nucleophilic attack, rendering the synthesis of the target challenging. Herein, we disclose a convergent total synthesis of norsecurinamine B, highlighting the strategic design elements that effectively address this stereochemical challenge.