Sequential α/β-C–H Functionalization of Monosubstituted Aliphatic Alkenes
Monosubstituted alkenes are widely utilized in organic synthesis. Although remarkable progress has been made in chelation-assisted alkenyl C-H functionalization, monosubstituted aliphatic alkene remains a challenging target due to reactivity and selectivity issues. Herein, we report on the first sequential α/β-C-H functionalization of monosubstituted aliphatic alkenes derived from bishomoallyl amines. This protocol showed wide functionality tolerance and afforded C-H alkenylation and allylation as well as alkynylation products with excellent regio- and stereoselectivity.
Authors
- Bing Xie (ORCID: https://orcid.org/0000-0003-2335-5966)
- Guofu Zhong
- Xi Lu (ORCID: https://orcid.org/0000-0002-6900-4726)
- Xiaoli Li (ORCID: https://orcid.org/0000-0001-9689-9054)
- Chao Chen (ORCID: https://orcid.org/0000-0003-3080-052X)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-8734-3003)
- Yini Wang (ORCID: https://orcid.org/0000-0002-1154-6733)
- Chengxing Peng
Institutions
- Sinopec (China) (CN)
- Eastern Institute of Technology (NZ)
- Hangzhou Normal University (CN)
- Zhejiang Shuren University (CN)
- Eastern Institute of Technology, Ningbo
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c04175
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00