Effect of Pegcetacoplan on Aqueous Humor Proteome in Geographic Atrophy: A Prospective Exploration
This exploratory study suggests that pegcetacoplan modulates the AH proteome in GA. Although no changes in the target protein C3 were detected following treatment, significant changes in proteins tightly connected to complement, inflammation, and coagulation were observed. These findings underscore the need for further investigation into the biological and clinical relevance of the observed molecular shifts.
Authors
- Yara Lechanteur (ORCID: https://orcid.org/0000-0003-0951-4625)
- Alain J. van Gool (ORCID: https://orcid.org/0000-0003-0010-5286)
- Caroline C. W. Klaver (ORCID: https://orcid.org/0000-0002-2355-5258)
- J. Cao (ORCID: https://orcid.org/0009-0003-8237-6684)
- Omer Trivizki
- Charles C. Wykoff (ORCID: https://orcid.org/0000-0001-7756-5091)
- Joëlle Vergroesen (ORCID: https://orcid.org/0000-0002-6093-4302)
- Avery Zhou
- Jolein Gloerich (ORCID: https://orcid.org/0000-0001-5976-8426)
- David Rabinovitch (ORCID: https://orcid.org/0000-0003-4970-7747)
- Lambert van den Heuvel
- Magda A. Smoor
Institutions
- University of Miami (US)
- Radboud University Nijmegen (NL)
- Tel Aviv University (IL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Retina Consultants of Texas (US)
- Radboud Institute for Molecular Life Sciences (NL)
- Miami Dermatology and Laser Institute (US)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- KU Leuven (BE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1167/iovs.66.15.24
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Retina Research Foundation
- Stichting Steunfonds Uitzicht
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Astellas Pharma
- Oogfonds
- Landelijke Stichting voor Blinden en Slechtzienden