Conformational Dynamics of PKM2 Regulate Hypoxia-Induced Pathological Retinal Angiogenesis
PKM2 conformational dynamics represents a novel regulatory mechanism of hypoxia-induced retinal neovascularization. Transformation of PKM2 tetramers induced by DASA-58 may provide a sound therapeutic approach for neovascular diseases including retinopathy of prematurity (ROP).
Authors
- Qing Chang (ORCID: https://orcid.org/0000-0003-4288-9736)
- Pei‐Wen Zhu (ORCID: https://orcid.org/0000-0002-6361-2923)
- Hao Chang (ORCID: https://orcid.org/0000-0001-5836-0728)
- Wenwen Chen (ORCID: https://orcid.org/0000-0003-0277-0941)
- Qian Yang (ORCID: https://orcid.org/0000-0002-5671-8412)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shandong Eye Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1167/iovs.66.15.23
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00