Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease
SMS2 promotes DED progression by driving oxidative stress-induced lipid dysregulation and NF-κB activation. SMS2 deficiency attenuates ocular surface damage, restores tear function, and suppresses inflammation, identifying SMS2 as a therapeutic target for DED.
Authors
- Jiaxu Hong
- Qihua Le (ORCID: https://orcid.org/0000-0001-7655-3101)
- Yiteng Lu
- Qingye Zhang (ORCID: https://orcid.org/0000-0002-9596-590X)
- Xichen Wan (ORCID: https://orcid.org/0000-0002-4550-0178)
- Mingrui Cheng
- Yuqing Wu (ORCID: https://orcid.org/0009-0001-1409-6993)
- Yang Cao (ORCID: https://orcid.org/0000-0002-3552-9153)
- Xujiao Zhou (ORCID: https://orcid.org/0000-0002-9719-4889)
- Runhan Shi (ORCID: https://orcid.org/0000-0001-7352-2967)
- Han Ye (ORCID: https://orcid.org/0000-0002-9119-4781)
- Xingyu Zhu (ORCID: https://orcid.org/0009-0001-8392-369X)
- Yirou Zhang
- Jingyuan Wang
Institutions
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Eye & ENT Hospital of Fudan University (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1167/iovs.66.15.22
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Municipal Education Commission
- Shandong First Medical University
- National Key Research and Development Program of China
- National Science Fund for Distinguished Young Scholars