Pinoresinol enhances intestinal tight junction integrity via activation of the CaMKKβ–AMPKα1 pathway in Caco-2 cells
This study identifies pinoresinol as a dietary bioactive compound that strengthens the intestinal barrier via activation of the CaMKKβ-AMPKα1 signaling axis. These findings provide mechanistic insight into its potential use as a functional ingredient for maintaining gut integrity and promoting overall intestinal health.
Authors
- Seulgi Shin (ORCID: https://orcid.org/0009-0007-9868-973X)
- Ha‐Young Park (ORCID: https://orcid.org/0000-0002-9450-8299)
- Young‐Min Kim (ORCID: https://orcid.org/0000-0002-2559-9182)
Institutions
- Chonnam National University (KR)
- Korea Atomic Energy Research Institute (KR)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12263-025-00788-3
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea