C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling
CNP suppresses apoptosis of granulosa cells through a PKG-independent mechanism involving transcriptional downregulation of apoptosis-related pathways. PKG appears to promote, rather than mediate, apoptosis in this system. Inhibition of PKG during IVM may improve oocyte quality and provide a useful reference for optimization of in vitro maturation systems.
Authors
- Lei An (ORCID: https://orcid.org/0000-0001-8509-2466)
- Guangyin Xi (ORCID: https://orcid.org/0000-0001-5997-6540)
- Yingjie Wu (ORCID: https://orcid.org/0009-0002-4280-5555)
- Qi Liu (ORCID: https://orcid.org/0000-0002-3078-3785)
- Deng Hong (ORCID: https://orcid.org/0000-0001-9164-7755)
- Yi Wei (ORCID: https://orcid.org/0000-0002-7600-0782)
- Jianhui Tian
Institutions
- Ministry of Agriculture (ID)
- Ministry of Agriculture and Rural Affairs (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13048-025-01879-w
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China