Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application
Our data-driven approach reveals specific neural connectivity disruptions in OA, highlighting connections between the cingulate gyrus, temporal lobe, and thalamus. These findings identify specific network disruptions in OA-related pain, offering insight into altered brain connectivity and potential avenues for targeted interventions.
Authors
- Varina L. Boerwinkle (ORCID: https://orcid.org/0000-0002-1429-2994)
- Belfin Robinson (ORCID: https://orcid.org/0009-0009-2792-3650)
- Ellora Srabani
- Vibhor Krishna (ORCID: https://orcid.org/0000-0002-4141-4192)
- Emilio G. Cediel (ORCID: https://orcid.org/0000-0002-4940-1070)
- William Reuther (ORCID: https://orcid.org/0000-0002-5573-1367)
- Olivia Leggio
- Aryan Kodali
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12880-025-02009-0
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00