UBE2S-mediated deubiquitination of GLUT1 via USP10 regulates glucose metabolic reprogramming and immune microenvironment to promote fibrosis in endometriosis
This study reveals the molecular mechanism by which the UBE2S-USP10-GLUT1 axis regulates the immune microenvironment and promotes fibrosis in EM through metabolic reprogramming. Our findings provide new insights into the pathogenesis of EM and offer a theoretical basis for targeting UBE2S in therapeutic strategies.
Authors
- Baoju Wang (ORCID: https://orcid.org/0000-0001-6942-570X)
- Hu Li (ORCID: https://orcid.org/0000-0002-5926-4591)
- Han Wu (ORCID: https://orcid.org/0000-0002-8996-2024)
- Guangmei Zhang (ORCID: https://orcid.org/0000-0002-4014-8646)
- Yan Cheng (ORCID: https://orcid.org/0000-0002-5977-6650)
- Yue Yin
- Linyao Zheng
- Zhen Zhang (ORCID: https://orcid.org/0000-0003-0357-5590)
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12967-025-07436-9
- Citations
- 1
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.70