Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols
We hope this practical guide will aid in improving pre-registration and reporting of TSAs of dichotomous outcomes within systematic review protocols with meta-analysis of randomised clinical trials in the future.
Authors
- Christian Gluud (ORCID: https://orcid.org/0000-0002-8861-0799)
- Joachim Birch Milan (ORCID: https://orcid.org/0000-0001-7093-5432)
- Christina Dahl Madsen (ORCID: https://orcid.org/0009-0002-9764-7144)
- Markus Harboe Olsen (ORCID: https://orcid.org/0000-0003-0981-0723)
- Vibeke Wagner (ORCID: https://orcid.org/0000-0002-1712-1648)
- Sigurlaug Hanna Hafliðadóttir (ORCID: https://orcid.org/0000-0002-7570-565X)
- Sophie Juul (ORCID: https://orcid.org/0000-0002-6171-2904)
- Zheng‐Yii Lee (ORCID: https://orcid.org/0000-0003-4505-7476)
- Charles Chin Han Lew (ORCID: https://orcid.org/0000-0001-6410-3859)
- Johanne Pereira Ribeiro (ORCID: https://orcid.org/0000-0001-6019-022X)
- Christian Gunge Riberholt (ORCID: https://orcid.org/0000-0002-6170-1869)
- Julie Perrine Schaug (ORCID: https://orcid.org/0000-0002-1283-4024)
- M. Asante (ORCID: https://orcid.org/0009-0002-8034-4139)
- Buddheera W.M.B. Kumburegama (ORCID: https://orcid.org/0009-0003-0698-0775)
- Jeppe Houmann Svanholm (ORCID: https://orcid.org/0000-0002-1131-2216)
- Elisabeth Buck Pedersen (ORCID: https://orcid.org/0009-0000-2333-7405)
Institutions
- University of Copenhagen (DK)
- Singapore Institute of Technology (SG)
- University of Southern Denmark (DK)
- Region Zealand (DK)
- Aalborg University Hospital (DK)
- Mental Health Services (DK)
- Glostrup Hospital (DK)
- Ng Teng Fong General Hospital (SG)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University of Malaya (MY)
- Akureyri Hospital (IS)
- Psychiatry Region Zealand (DK)
- Charité - Universitätsmedizin Berlin (DE)
- IT University of Copenhagen (DK)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12874-025-02716-w
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Copenhagen Trial Unit, Centre for Clinical Intervention Research