Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols

We hope this practical guide will aid in improving pre-registration and reporting of TSAs of dichotomous outcomes within systematic review protocols with meta-analysis of randomised clinical trials in the future.

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Publication Details

Journal
BMC Medical Research Methodology
Published
2025-12-05
DOI
https://doi.org/10.1186/s12874-025-02716-w
Primary Topic
Meta-analysis and systematic reviews
Type
article
Field-Weighted Citation Impact
0.00

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article

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols

Christian Gluud, Joachim Birch Milan, Christina Dahl Madsen, Markus Harboe Olsen et al.
BMC Medical Research Methodology
Meta-analysis and systematic reviews
article

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols

Christian Gluud, Joachim Birch Milan, Christina Dahl Madsen, Markus Harboe Olsen, Vibeke Wagner, Sigurlaug Hanna Hafliðadóttir, Sophie Juul, Zheng‐Yii Lee, Charles Chin Han Lew, Johanne Pereira Ribeiro, Christian Gunge Riberholt, Julie Perrine Schaug, M. Asante, Buddheera W.M.B. Kumburegama, Jeppe Houmann Svanholm, Elisabeth Buck Pedersen
article en

Abstract

We hope this practical guide will aid in improving pre-registration and reporting of TSAs of dichotomous outcomes within systematic review protocols with meta-analysis of randomised clinical trials in the future.

BMC Medical Research MethodologyVol. 25(1)
University of Copenhagen (DK), Singapore Institute of Technology (SG), University of Southern Denmark (DK), Region Zealand (DK), Aalborg University Hospital (DK), Mental Health Services (DK), Glostrup Hospital (DK), Ng Teng Fong General Hospital (SG), Copenhagen University Hospital (DK), Rigshospitalet (DK), University of Malaya (MY), Akureyri Hospital (IS), Psychiatry Region Zealand (DK), Charité - Universitätsmedizin Berlin (DE), IT University of Copenhagen (DK)
Copenhagen Trial Unit, Centre for Clinical Intervention Research
Openalex Percentile: Top 63%
Meta-analysis and systematic reviews
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