Genetic insights into drug targets for alzheimer’s disease: integrative multi-omics analysis
This study established a comprehensive AD target atlas, revealing mechanism-anchored targets that were validated across multiomics analyses and a clinically actionable framework integrating efficacy, biology, and safety profiling. Overall, these results advance AD drug discovery by revealing prioritized targets with causal biological support and providing a validated development roadmap.
Authors
- Xiaoduo Liu
- Shaojiong Zhou (ORCID: https://orcid.org/0000-0002-9808-3312)
- Jia Chen (ORCID: https://orcid.org/0000-0003-3220-4852)
- Jianfeng Lin (ORCID: https://orcid.org/0000-0002-0181-5899)
Institutions
- University of Electronic Science and Technology of China (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The Fourth People's Hospital (CN)
- National Cancer Center (US)
- Fourth People's Hospital of Sichuan Province (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13195-025-01901-9
- Citations
- 1
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82