Homologous recombination repair status in advanced endometrial cancer: an exploratory biomarker analysis from the randomized, phase II MITOEND 3 trial
A small subgroup of advanced EC patients shows HRD positivity by gLOH or HRDsig, potentially identifying those most likely to benefit from PARP inhibitors. These tumors are typically endometrioid with TP53 mutations.
Authors
- Stefano Tamberi (ORCID: https://orcid.org/0000-0002-7087-9116)
- Alberto Farolfi (ORCID: https://orcid.org/0000-0002-3289-8041)
- Saverio Cinieri (ORCID: https://orcid.org/0000-0002-5555-0814)
- Anna Passarelli (ORCID: https://orcid.org/0000-0003-4643-7809)
- Ethan Sokol (ORCID: https://orcid.org/0000-0002-5480-8473)
- Laura Arenare (ORCID: https://orcid.org/0000-0001-7100-4517)
- Carmela Pisano (ORCID: https://orcid.org/0000-0003-4577-6534)
- V. Ghizzoni (ORCID: https://orcid.org/0000-0001-6443-8253)
- Michele Bartoletti (ORCID: https://orcid.org/0000-0002-9631-5693)
- Claudia De Angelis (ORCID: https://orcid.org/0000-0003-0398-5610)
- Daniela Califano (ORCID: https://orcid.org/0000-0001-6945-3209)
- Claudio Andreetta
- Clorinda Schettino
- Rossella De Cecio (ORCID: https://orcid.org/0000-0001-9779-7076)
- Domenica Lorusso (ORCID: https://orcid.org/0000-0003-0981-0598)
- Saumya D. Sisoudiya (ORCID: https://orcid.org/0000-0001-7276-8084)
- Anna Spina (ORCID: https://orcid.org/0000-0002-4726-9299)
- Anna Fagotti (ORCID: https://orcid.org/0000-0001-5579-335X)
- Daniela Russo (ORCID: https://orcid.org/0000-0001-9471-1935)
- Giovanni Luca Scaglione (ORCID: https://orcid.org/0000-0001-5622-7843)
- Filippo Greco (ORCID: https://orcid.org/0009-0004-9568-5029)
- Francesco Perrone (ORCID: https://orcid.org/0000-0002-9738-0526)
- S Pignata
Institutions
- Humanitas University (IT)
- Boston Foundation (US)
- Agostino Gemelli University Polyclinic (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale A. Perrino (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Centro di Riferimento Oncologico (IT)
- Regione del Veneto (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105919
- Citations
- 1
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.06